Stephanie Leonidas plays the part of the somewhat exotic, and extremely knife happy "Irathient" Irisa with the pron-star red hair, an orphan who has been raised by the the shoot-em up sheriff Joshua Nolan, all purpose warrior, played by Grant Bowler.
The town's new human mayor, Amanda Rosewater, is played by Julie Benz, a Buffy graduate, and numerous other roles. By virtue of playing a human, I'm sure she's spared hours of makeup. And she gets to wear the cool pleather pseudo-western clothes, too.
Jaime Murray, who has the dubious honor of having a second shot at a SciFi Rule 5 post fame, her first having been in one on the girls of Warehouse 13.
Finally, we have the Miss Kitty of Defiance, Kenya Rosewater, played by Mia Kirshner. For those too young to remember, Miss Kitty ran the Long Branch Saloon and brothel, although they never exactly said so, in Marshall Matt Dillon's "Gunsmoke." Kenya was last seen dry humping some guy with an alien monster erupting from his chest.
More pictures of the Girls of Defiance below the jump
Now linked at Wombat-Socho's ginourmous three week make-up "Rule 5 Sunday: Cinco de Mayo Massive Catching-Up Edition" at The Other McCain.