Friday, September 18, 2020

Enough WuFlu for You? Part 3 - HCQ and Other Treatments

Still trying to beat back the mold growing in the digital fridge. Buzzfeed asks, Can Hydroxychloroquine Prevent COVID-19? We’ll Probably Never Know. These Scientists Are Still Studying The World’s Most Controversial Drug, But They Can’t Find Enough People To Take It. "Scientists launched clinical trials to see if a malaria drug could prevent COVID-19. What happened next shows how politicized and disorganized coronavirus research has become." Matt Margolis at PJ Media asks Is the CDC Downplaying the Efficacy of Hydroxychloroquine To 'Resist' Trump? I know government employees, and I believe it entirely possibel. 

As PJM’s Stacey Lennox noted yesterday, Health and Human Services Assistant Secretary for Public Affairs Michael Caputo recently warned on Facebook live that the Centers for Disease Control and Prevention (CDC) “was harboring a ‘resistance unit’ to Trump.”

Caputo alleged that career scientists “haven’t gotten out of their sweatpants except for meetings at coffee shops” to plot “how they’re going to attack Donald Trump.”

“There are scientists who work for this government who do not want America to get well, not until after Joe Biden is president,” Caputo added.

A real study,  Low-dose hydroxychloroquine therapy and mortality in hospitalised patients with COVID-19: a nationwide observational study of 8075 participants

  • Hydroxychloroquine (HCQ) 2400 mg over 5 days was used in Belgium for COVID-19.
  • Impact of HCQ on mortality among 8075 patients with COVID-19 was assessed.
  • Lower mortality in HCQ-treated patients as compared to supportive care.•
  • Lower mortality was irrespective of symptom duration.

While at WUWT, Hydroxychloroquine in COVID-19 Treatment, Actual Usage in the USA

The analysis was focused on Hydroxychloroquine (HCQ). This study has found that Hydroxychloroquine (HCQ) was used for the treatment of COVID-19 in the US since January 2020. From January to August 16, 13.5% of COVID-19 patients ages 40+ were prescribed Hydroxychloroquine in the US.

Chris Smith at NYPo, Scientists can’t explain puzzling lack of coronavirus outbreaks in Africa. Tow things. The disease is slower and less deadly in the tropics, the people average younger and use of hydroxycholorquine is widespread due to malaria. There may be lots of pre-existing immunity due to previous coronaviruses infections. 

Victory Girls, HCQ and Lysenkoism 2.0

Bryan Fischer, Principa Scientific, Fauci Knew About HCQ In 2005 – Nobody Needed To Die and from RCP via MSN, Mikko Paunio  Dr. Fauci’s Hydroxychloroquine Denial

And, sadly, Dr. Fauci's fave? American Council on Science and Health Remdesivir Disappoints. Again.
An 11-day randomized Phase 3 trial of almost 600 patients, all with moderate COVID, was conducted to compare the clinical status (2) of three groups (~200 patients each) on day 11:
  1. patients who received remdesivir for 5 days
  2. patients who received remdesivir for 10 days
  3. patients who received standard care
The findings were a bit strange. On day 11, patients who had received five days of remdesivir showed a statistically significant improvement compared to those who received standard care but not a clinically significant difference. And the patients who received a 10-day course (3) of the drug experienced no difference, either statistically or clinically.
UPI, Dexamethasone, other corticosteroids help hospitalized COVID-19 patients, or as NYPo puts it, Cheap steroids can cut COVID-19 deaths by a third: study.

But that will be a while. In the meantime, take your vitamin D, JAMA, Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results. I take it now, even though I get plenty of sun, at least in summer. 
In this cohort study of 489 patients who had a vitamin D level measured in the year before COVID-19 testing, the relative risk of testing positive for COVID-19 was 1.77 times greater for patients with likely deficient vitamin D status compared with patients with likely sufficient vitamin D status, a difference that was statistically significant.

BGR, Doctors found a new drug that might block coronavirus infections

Vacuolin-1 and apilimod were developed years ago and they target an enzyme called PIKfyve kinase. This enzyme has a role in the COVID-19 infection, which is why the drugs might work. Tomas Kirchhaused, professor of cell biology in the Blavatnik Institute at HMS and professor of pediatrics at Boston Children’s, discovered vacuolin-1 16 years ago. Apilimod was developed by LAM Therapeutics. The two drugs are similar and they can both block the Ebola virus, researchers found a few years ago. Those studies were continued once the novel coronavirus arrived, as Kirchhausen realized that the kinetics of cell entry in Ebola and COVID-19 are similar.

WaPoo, EPA approves coronavirus cleanser for emergency use in Texas 

The agency said it hoped the product — called SurfaceWise2 and made by Allied BioScience — would provide longer-lasting protection in public spaces and increase consumer confidence in air travel, which has suffered a big hit during the covid-19 pandemic.

UPI,  Nasal solution may stop spread of COVID-19, study finds. A common iodine compound. But the article is not clear on when or why. 

Also, UPI, Small study supports donor plasma therapy for severe COVID-19. Alex Nitzberg at JTN, Trump announces emergency authorization for convalescent plasma in battle against coronavirus and all of a sudden, Democrats and the media found themselves opposed. WaPoo whines, Some Trump administration claims on effectiveness of convalescent plasma are wrong or dubious, scientists say. Red State, MSNBC’s Maddow Breaks in to ‘Fact-Check’ Trump on Plasma; SHE Gets FACT-CHECKED to a Crisp

Yahoo! Best bet to beat COVID-19 this fall? Flu shots. But not the way you think.
As most doctors will tell you, hospitals approach peak capacity every year during flu season. I know this because I'm one of those doctors. What would have happened if flu season took place during this summer's COVID surge?

As scientists worldwide race for a vaccine, there's another way we can beat COVID-19: It's called the flu shot. And it's our best chance against the nightmarish "worst fall" in public health history, as warned by officials from the Centers for Disease Control and Prevention.

This is the most important flu shot of the century.

I plan to, and we always do. 

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