Monday, July 28, 2025

The Monday Morning Stimulus

a new study published in the European Journal of Pharmacology has me reconsidering how I go about my coffee drinking habits.

According to their findings, drinking coffee before high-stress situations can regulate the gut-brain axis and, subsequently, could stave off feelings related to depression and anxiety.

Using a mouse model, researchers deduced that early caffeine intervention can help prevent stress-induced depression. They ran a chronic unpredictable stress paradigm on two groups of mice, one of which was pre-administered daily injections of caffeine before stress exposure. The others completed the experiment without treatment. A third class of mice, which didn’t undergo treatment or testing, served as the control group.

“This preventive design allows us to explore whether caffeine can mitigate the development of stress-induced depression, rather than merely alleviating symptoms after they have already manifested,” explained the authors.

The Wombat has Rule 5 Sunday: Gother Than Thou up and garnering clicks at The Other McCain.









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